|Statement||[sponsored by] Schering Corporation ; editors, Robert M. Friedman, Thomas Merigan, T. Sreevalsan.|
|Series||UCLA symposia on molecular and cellular biology ;, new ser., v. 50|
|Contributions||Friedman, Robert M. 1932-, Merigan, Thomas C., 1934-, Sreevalsan, T., Schering Corporation., UCLA Symposium on Interferons as Cell Growth Inhibitors and Antitumor Factors (1986 : Steamboat Springs, Colo.)|
|LC Classifications||QR187.5 .I575 1986|
|The Physical Object|
|Pagination||xxxviii, 541 p. :|
|Number of Pages||541|
|LC Control Number||86021402|
Get this from a library! Interferons as cell growth inhibitors and antitumor factors: proceedings of a Schering Corporation-UCLA Symposium held in Steamboat Springs, Colorado, April , [Robert M Friedman; Thomas C Merigan; T Sreevalsan; Schering Corporation.;]. Read "Interferons as cell growth inhibitors and antitumor factors, Journal of Cellular Biochemistry" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Title(s): Interferons as cell growth inhibitors and antitumor factors: proceedings of a Schering Corporation-UCLA Symposium held in Steamboat Springs, Colorado, April , / editors, Robert M. Friedman, Thomas Merigan, T. Sreevalsan. Interferons are potent cell growth inhibitors, but the biochemical events that mediate such activity are poorly understood. The existence of second messengers conveying signals originating from the cell membrane upon interaction of interferon and its receptors have been by: 4.
Interleukin-1 (IL-1), fibroblast growth factors (FGFs), and their homologues are secreted factors that share a common β-barrel structure and act on target cells by binding to cell surface. Interferons (IFNs) are a class of glycoprotein cytokines produced by lymphocytes in response to infection by pathogens. The name Interferons is derived from the ability to interfere with virus replication. There are 3 distinct types of interferons - type I, II and III. Type 1 IFNs include IFN-alpha and IFN-beta and others such as IFN-omega, -epsilon, -kappa and -tau; this type is . Types of interferon. Based on the type of receptor through which they signal, human interferons have been classified into three major types.. Interferon type I: All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α/β receptor that consists of IFNAR1 and IFNAR2 chains. The type I interferons present in humans are IFN-α, IFN-β, IFN-ε, IFN-κ and ro: IPR Interferon (3 M IU × 3 times weekly for ∼ weeks) and rituximab ( mg per lesion, 3 times weekly for 1 week, possibly repeated 4 weeks later) are sometimes used in the management of.
Early clinical studies. The discovery of interferons was a result of research by Isaacs & Lindenmann in the field of viral interference , the ability of an active or inactivated virus to interfere with the growth of an unrelated , viral interference had been considered to be due directly to the action of one virus on the pathologic activity of a second Cited by: A direct negative effect on cell growth would, of course, be an ideal mechanism of action for an antitumor substance. In many respects IFNs would seem to be negative growth control factors. Thus, they are an unusual class of biological substances, since almost all growth factors that have been studied stimulate cell by: 1. Abstract. Interferons (IFNs) are a family of proteins sharing the capacity to exert distinctive effects on cell functions. Their most prominent property and the one by which they have been recognized (Isaacs and Lindenmann ) is their capacity to render cells resistant to virus growth. Suppression of cell growth. The prominent characteristic of tumor cells is their uncontrolled division, which overrides the checkpoints that normally keep cell division in check. Thus, one of the aims of drugs and other non-surgical therapies is to control the development of tumors through suppression of cell growth and by: 2.